For both clinical and economic reasons, the increasing number of persons living with chronic health conditions such as chronic pain, Lyme disease, somatic symptom disorder and others, represents a public health concern of growing urgency. Emphasizing patient responsibility and acting in a collaborative nature in concert with the provider community, self-management represents a promising strategy for treating chronic disease. Clinically working with individuals to actively identify challenges and self-solve problems associated with their chronic illness decreases physician office visits, unnecessary surgical interventions and billions of unnecessary dollars spent on products claiming to cure the presenting disease. Self-management also shows potential as an effective paradigm across the prevention spectrum (primary, secondary, and tertiary) by establishing a pattern for health as early in the treatment episode as possible and providing strategies for mitigating illness and managing it in later life. Practical applications of self-management of chronic disease will be discussed in this presentation.