In this session, Dr. Robin Carhart-Harris reviews findings from recent clinical trials conducted with colleagues at, or formerly at, Imperial College London. He will discuss a pilot trial of psilocybin therapy for anorexia nervosa, involving 21 participants with outcomes collected for up to 12 months. The presentation will focus on the study’s motivation, methodology including MRI and EEG measures and results, situating them within the broader context of current anorexia treatments and psychedelic medicine research. He will also present findings from a mechanistic trial of psilocybin therapy in fibromyalgia syndrome, involving 20 participants. The study utilized pre- and post-treatment fMRI along with EEG during dosing sessions. Dr. Carhart-Harris will explain the rationale, findings, and relevance to the broader field of chronic pain treatment Additionally, he will review the 2021 New England Journal of Medicine trial comparing psilocybin therapy with escitalopram for major depressive disorder, covering the trial’s inspiration, observations, publication process, and resulting conclusions and future directions.