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Metabolic Synergy: Adjunctive Interventions that Enhance Ketogenic Metabolic Therapies for Mental Health

Matt Bernstein, MD
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Date & Time

Description

Emerging evidence indicates that metabolic and circadian regulation are fundamental to mental well-being. While the ketogenic diet improves cellular energy metabolism and psychiatric symptoms, its benefits can be magnified by complementary behavioral and supplemental interventions.

This session reviews evidence-based strategies that synergize with ketogenic therapy to optimize metabolic and brain health.

We will highlight structured exercise as a modulator of insulin sensitivity, neuroplasticity, and mood; circadian alignment strategies (light exposure, sleep timing, and meal scheduling) that stabilize metabolic and emotional rhythms; and mind-body practices—including meditation, breath regulation, and relaxation response training—that promote parasympathetic dominance, lower allostatic load, and enhance mitochondrial renewal.

Practical approaches to reduce postprandial glucose excursions and targeted nutraceuticals (e.g., creatine, urolithin A) that support cellular energetics will also be discussed.

Participants will gain a unified, evidence-informed framework for integrating adjunctive metabolic and mind-body strategies to amplify the mental-health benefits of ketogenic interventions.

Learning Objectives

Participants will be able to:

  • Describe the shared physiological mechanisms—such as mitochondrial biogenesis, autonomic regulation, and circadian alignment—through which metabolic and mind-body interventions enhance brain health and resilience.

  • Identify evidence-based adjunctive strategies that synergize with ketogenic therapy, including structured exercise, circadian rhythm optimization, mind-body practices, and nutraceutical supports.

  • Apply practical, personalized approaches to integrate these metabolic and behavioral interventions into clinical care to improve mental-health and metabolic outcomes

Educational Goal

The educational goal of this workshop is to provide participants with a practical, evidence-based framework for enhancing ketogenic therapy with metabolic, circadian, and mind–body strategies to support mental health.

Target Audience

  • Addiction Professional
  • Counselor
  • Dietitian
  • Marriage & Family Therapist
  • Nurse
  • Nutritionist
  • Physician
  • Social Worker

Presenters

Matt Bernstein, MD
Dr. Matt Bernstein is a highly respected clinical psychiatrist and a leading voice in metabolic psychiatry, with 25 years of experience helping individuals achieve full mental health and functional recovery.

He graduated summa cum laude from Columbia University in English literature and earned his medical degree from the Perelman School of Medicine at the University of Pennsylvania. Trained at MGH/McLean, he served as chief resident and later held leadership roles including psychiatrist-in-charge and assistant medical director of the schizophrenia and bipolar inpatient program. He also serves as chief medical officer at Ellenhorn, developing community-based strategies to optimize mental health.

For the past five years, Dr. Bernstein has focused on metabolic psychiatry, first in his private practice and then at Ellenhorn. More recently, he created Accord’s comprehensive program and is sharing his expertise through podcasts, national conferences, and briefings for members of Congress. He co-organized the first public conference on metabolic psychiatry and co-leads a privately funded study evaluating outcomes of Accord’s pioneering interventions. He serves on advisory and non-profit boards, including Metabolic Mind, Meru Health, The Metabolic Revolution, and the Coalition for Metabolic Health, helping advance the field both clinically and publicly.

Financially Sponsored By

  • Accord